Two men were traveling along Congress Run Road in a Jeep Wrangler when it went off the road and into an embankment. One man was ejected from the vehicle while the driver was trapped inside.
Ohio State Highway Patrol, Little Hocking, and Belpre all responded to the crash.
A helicopter was called to the scene but was cancelled before it arrived.
The conditions of two men are not available at this time.
The cause of the crash is still under investigation.