The Parkersburg Fire Department says the fire at a Market Street apartment is being investigated as an arson.
Fire inspector Tim Flinn told WTAP the fire was "incendiary". Police are now investigating.
Officials say the fire broke out around 1 am Tuesday morning on the first floor of 1133 Market Street.
Captain Brian Drake says first reports indicated a woman was trapped inside the building.
After forcing entry into the apartment and extinguishing a fire in the main room, Drake says firefighters found the apartment empty.
He says no one was harmed.
Officials say the apartment is a total loss, but other units inside the building were unharmed.
Nearly 45 minutes after blaze the building was ventilated and residents were allowed back in.
We will keep you updated with the latest.