It happened around 9 o'clock Monday night near the intersection of 19th and Oak Streets in Parkersburg.
Parkersburg police say Vincent Plummer was driving east on 19th Street when he hit an unoccupied, parked car. He continued down the street, driving head-on into a Nissan Altima with two people inside.
Both were transported to Marietta Memorial Hospital with non-life threatening injuries.
Plummer is charged with DUI.