East Tennessee State led the entire second half and held off Marshalll 79-73 in Johnson City, Tennessee.
Marshall got to within 73-68 with 1:18 left on a 3-pointer by Matt Walls. ETSU's Dequan Twilley then made 6 of 8 free throws the rest of the way for the victory.
Walls led Marshall with 21 points. Tirrell Baines had 15, Markel Humphrey scored 14 and Mark Dorris had 11.
Kevin Tiggs scored 24 points to lead ETSU. Twilley finished with 15 points and Courtney Pigram scored 14.
The Bucs shot 54 percent for the game. Marshall shot just 38.8 percent from the floor, including just 9-of-32 3-pointers.
The Bucs had a 10-point advantage at the free throw line, hitting 22-of-38 to 12-of-18 by Marshall.
Marshall trailed 35-31 at halftime.