Right-hander Woody Williams singled home a run in the fourth inning to set up his first victory for Houston as the Astros won 3 to 2 over the slumping Cincinnati Reds.
Lance Berkman homered for the third game in a row tonight, and Houston improved to 7-and-1 against the Reds this season -- including 5-and-Oh at Great American Ball Park.
Cincinnati's Adam Dunn hit his tenth home run.
But the Reds committed three errors and fell into last place in the N-L Central with their seventh loss in eight games.
They have a ten-game deficit for the first time since the end of the 2005 season, when they finished 27 back.